Professor Degenhardt is an NHMRC Principal Research Fellow at the National Drug and Alcohol Research Centre, University of New South Wales. She has worked across a wide range of projects examining the epidemiology of illicit drug use, comorbid mental health problems, and illicit drug surveillance. From 2001-2008 she established and expanded national illicit drug surveillance and strategic early warning systems across Australia, and was appointed a Professor of Epidemiology in 2007. She is involved in diverse epidemiological studies, including examination of mortality related to opioid antagonist treatment; post marketing surveillance of new opioid agonist pharmacotherapies; data linkage studies of opioid substitution therapy (OST) entrants examining the impacts of OST upon crime, recidivism and mortality; and multiple prospective cohort studies including a study of people living with chronic non-cancer pain who are prescribed pharmaceutical opioids. Professor Degenhardt is involved in ongoing national and international projects, for example working with WHO and UNAIDS on the epidemiology of illicit drug use and associated health risks across the globe. She was the lead academic on the Secretariat for the Reference Group to the United Nations on Injecting Drug Use and HIV (2007-2010), and chaired the Illicit Drug Use Disorders expert group for the 2010 Global Burden of Disease Study. She is a member of the Technical Advisory Group for the 11th revision of the International Classification of Diseases (ICD) Injury and External Causes of Injury.